PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery.

doi:10.1016/j.soard.2016.06.004

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Article

PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery - 1 Dec 2016

Krawczyk Marcin, Jiménez-Agüero Raúl, Alustiza José M, Emparanza José I, Perugorria María J, Bujanda Luis, Lammert Frank, Banales Jesús M

Abstract excerpt

BACKGROUND: Obesity is the major trigger of nonalcoholic fatty liver disease (NAFLD). NAFLD is further favored by the patatin-like phospholipase domain-containing 3 (PNPLA3) p.I148M, transmembrane 6 superfamily member 2 (TM6SF2) p.E167K, and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 variants. OBJECTIVES: To investigate the relationship between the PNPLA3, TM6SF2, and MBOAT7 genotypes...

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Source

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Identifiers

PMID: 27576208
DOI: 10.1016/j.soard.2016.06.004

Genes

PNPLA3
MBOAT7

Variants

rs641738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery.PMID 27576208Read ↗

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Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study.Semantic proximity Read ↗

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