PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals.

doi:10.1016/j.dld.2012.05.006

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Article

PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Dec 2012

Burza Maria Antonella, Pirazzi Carlo, Maglio Cristina, Sjöholm Kajsa, Mancina Rosellina Margherita, Svensson Per-Arne, Jacobson Peter, Adiels Martin, Baroni Marco Giorgio, Borén Jan, Ginanni Corradini Stefano, Montalcini Tiziana, Sjöström Lars, Carlsson Lena Mariana Susann, Romeo Stefano

Abstract excerpt

BACKGROUND: Obesity is a risk factor for cancer, including hepatocellular carcinoma. Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) genetic variant has been associated with hepatocellular carcinoma (HCC) in individuals with chronic alcohol abuse or hepatic viral infection. In the present study we examined the association between the PNPLA3 I148M genetic variant and hepatocellular...

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Identifiers

PMID: 22704398
DOI: 10.1016/j.dld.2012.05.006

Genes

PNPLA3

Variants

rs738409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals.PMID 22704398Read ↗

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.Semantic proximity Read ↗

PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease.Semantic proximity Read ↗

PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery.Semantic proximity Read ↗

The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.Semantic proximity Read ↗

The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrientsSemantic proximity Read ↗

PNPLA3 I148M and Hepatocellular Carcinoma.Semantic proximity Read ↗

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.Semantic proximity Read ↗

PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.Semantic proximity Read ↗

I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.Semantic proximity Read ↗

PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver diseaseSemantic proximity Read ↗

Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis.Semantic proximity Read ↗

Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages.Semantic proximity Read ↗

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