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Article

Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function.

The FEBS journal - 1 Dec 2016

Nomikos Michail, Thanassoulas Angelos, Beck Konrad, Theodoridou Maria, Kew Jasmine, Kashir Junaid, Calver Brian L, Matthews Emily, Rizkallah Pierre, Sideratou Zili, Nounesis George, Lai F Anthony

Abstract excerpt

Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may exist as an isolated feature, or in simultaneous occurrence with other cutaneous or systemic pathologies. Associations between hereditary leukonychia and mutations in the gene encoding phospholipase C delta-1 (PLCδ1) have previously been identified. However,...

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Identifiers

PMID: 27783455
DOI: 10.1111/febs.13939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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