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Article

Emerging Roles of Xanthine Oxidoreductase in Chronic Kidney Disease

12 Jun 2024

Abstract excerpt

Xanthine Oxidoreductase (XOR) is a ubiquitous, essential enzyme responsible for the terminal steps of purine catabolism, ultimately producing uric acid that is eliminated by the kidneys. XOR is also a physiological source of superoxide ion, hydrogen peroxide, and nitric oxide, which can function as second messengers in the activation of various physiological pathways, as well as contribute to the development and...

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PMID: 38929151
DOI: 10.3390/antiox13060712

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