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Regulation of Induced Pluripotent Stem (iPS) Cell Induction by Wnt/β-Catenin Signaling

31 Jan 2014

Abstract excerpt

Wnt signaling has been implicated in promoting somatic cell reprogramming. However, its molecular mechanisms remain unknown. Here we report that Wnt/β-catenin enhances iPSCs induction at the early stage of reprogramming. The augmented reprogramming induced by β-catenin is not due to increased total cell population or activation of c-Myc. In addition, β-catenin interacts with reprogramming factors Klf4, Oct4, and...

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PMID: 24482235
DOI: 10.1074/jbc.m113.542845

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