Article
Modern Beijing sublineage of Mycobacterium tuberculosis shift macrophage into a hyperinflammatory status.
Emerging microbes & infections - 1 Dec 2022
Tong Jingfeng, Meng Lu, Bei Cheng, Liu Qingyun, Wang Min, Yang TingTing, Takiff Howard E, Zhang Shuye, Gao Qian, Wang Chuan, Yan Bo
Abstract excerpt
The high prevalence of the modern Beijing sublineage of Mycobacterium tuberculosis may be related to increased virulence, although the responsible mechanisms remain poorly understood. We previously described enhanced triacylglycerol accumulation in modern Beijing strains. Here we show that modern Beijing strains grow faster in vitro and trigger a vigorous immune response and pronounced macrophage infiltration....
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