Article
Mutations in the regulatory network underlie the recent clonal expansion of a dominant subclone of the Mycobacterium tuberculosis Beijing genotype.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2011
Schürch Anita C, Kremer Kristin, Warren Robin M, Hung Nguyen V, Zhao Yanlin, Wan Kanglin, Boeree Martin J, Siezen Roland J, Smith Noel H, van Soolingen Dick
Abstract excerpt
The Beijing genotype family is an epidemiologically important sub-group of Mycobacterium tuberculosis. It has been suggested that the high frequency of the Beijing isolates in some areas could be explained by selective advantages. Some evidence suggests that the emerging and most frequently isolated "Typical Beijing" lineage has the ability to circumvent BCG-induced immunity. To investigate the phylogeny of the...
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