Article
A recently evolved sublineage of the Mycobacterium tuberculosis Beijing strain family is associated with an increased ability to spread and cause disease.
Journal of clinical microbiology - 1 May 2007
Hanekom M, van der Spuy G D, Streicher E, Ndabambi S L, McEvoy C R E, Kidd M, Beyers N, Victor T C, van Helden P D, Warren R M
Abstract excerpt
This study aimed to reconstruct the evolutionary history of Beijing strains of Mycobacterium tuberculosis and to test the hypothesis that evolution has influenced the ability of the Beijing strains within the different Beijing sublineages to spread and cause disease. A PCR-based method was used to analyze the genome structure of 40 different loci in 325 Beijing isolates collected from new and retreatment...
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