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Article

An integrated approach to the meta-analysis of genetic association studies using Mendelian randomization.

American journal of epidemiology - 1 Sept 2004

Minelli Cosetta, Thompson John R, Tobin Martin D, Abrams Keith R

Abstract excerpt

A natural randomization process, sometimes called Mendelian randomization, occurs at conception to determine a person's genotype. By combining information from genotype-disease and genotype-phenotype studies, it is possible to use this Mendelian randomization to derive an estimate of the association between phenotype (risk factor) and disease that is free of the confounding and reverse causation typical of...

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Identifiers

PMID: 15321841
DOI: 10.1093/aje/kwh228

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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