Mendelian randomization analysis of case‐control data using structural mean models

Abstract excerpt

'Instrumental Variable' (IV) methods provide a basis for estimating an exposure's causal effect on the risk of disease. In Mendelian randomization studies, where genetic information plays the role of the IV, IV analyses are routinely performed on case-control data, rather than prospectively collected observational data. Although it is a well-appreciated fact that ascertainment bias may invalidate such analyses,...

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