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Article

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

BMJ (Clinical research ed.) - 15 Feb 2011

Wensley Frances, Gao Pei, Burgess Stephen, Kaptoge Stephen, Di Angelantonio Emanuele, Shah Tina, Engert James C, Clarke Robert, Davey-Smith George, Nordestgaard Børge G, Saleheen Danish, Samani Nilesh J, Sandhu Manjinder, Anand Sonia, Pepys Mark B, Smeeth Liam, Whittaker John, Casas Juan Pablo, Thompson Simon G, Hingorani Aroon D, Danesh John

Abstract excerpt

OBJECTIVE: To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease. DESIGN: Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries. PARTICIPANTS: 194 418 pa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21325005
DOI: 10.1136/bmj.d548
PMCID: PMC3039696

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21325005-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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