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Article

Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2012

Hu Jing, Liu Yan-Long, Piao Song-lin, Yang Dong-dong, Yang Yan-Mei, Cai Li

Abstract excerpt

BACKGROUND: Recent researches document that an oncogenic role of USP22 activation may contribute to progression and predict the prognosis. We have reported that USP22 mediates cell survival and proliferation by promoting the expression of BMI-1 and upregulation of activated AKT pathway in colon cancer cells. However, little is known about its mechanisms in non-small-cell lung cancer (NSCLC). Here the authors...

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Source

Identifiers

PMID: 22717106
DOI: 10.1016/j.lungcan.2012.05.112

Genes

USP22
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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