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Article

Toward the insulin-IGF-I intermediate structures: functional and structural properties of the [TyrB25NMePheB26] insulin mutant.

Biochemistry - 28 Dec 2004

Záková Lenka, Brynda Jirí, Au-Alvarez Oskar, Dodson Eleanor J, Dodson Guy G, Whittingham Jean L, Brzozowski Andrzej M

Abstract excerpt

The origins of differentiation of insulin from insulin-like growth factor I (IGF-I) are still unknown. To address the problem of a structural and biological switch from the mostly metabolic hormonal activity of insulin to the predominant growth factor activities of IGF-I, an insulin analogue with IGF-I-like structural features has been synthesized. Insulin residues Phe(B25) and Tyr(B26) have been swapped with the...

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PMID: 15610023
DOI: 10.1021/bi048856u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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