Article
Functional CYP1A1 genetic variants, alone and in combination with smoking, contribute to development of head and neck cancers.
European journal of cancer (Oxford, England : 1990) - 1 Jun 2013
Liu Li, Wu Gang, Xue Fang, Li Yunfeng, Shi Juan, Han Jianjun, Zhang Xiaojiao, Na Yan, Zhang Huaijin, Tang Xiaohu, Pu Honglei, Yuan Qipeng, Zhang Li, Yang Ming
Abstract excerpt
CYP1A1 plays an essential role in pathogenesis of head and neck cancers. Functional CYP1A1 Ile462Val and MspI single nucleotide polymorphisms (SNP) are considered to have significant effects on risk of head and neck cancers. Several case-control studies have examined how these genetic polymorphisms are involved in development of this group of malignancies, but the conclusions are inconsistent. Therefore, we...
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