Article
PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes.
Genetic epidemiology - 1 Apr 2012
Ried Janina S, Döring Angela, Oexle Konrad, Meisinger Christa, Winkelmann Juliane, Klopp Norman, Meitinger Thomas, Peters Annette, Suhre Karsten, Wichmann H-Erich, Gieger Christian
Abstract excerpt
Most genome-wide association studies (GWAS) are restricted to one phenotype, even if multiple related or unrelated phenotypes are available. However, an integrated analysis of multiple phenotypes can provide insight into their shared genetic basis and may improve the power of association studies. We present a new method, called "phenotype set enrichment analysis" (PSEA), which uses ideas of gene set enrichment...
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