Article
Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo.
Antimicrobial agents and chemotherapy - 1 Sept 2012
Murphey-Corb Michael, Rajakumar Premeela, Michael Heather, Nyaundi Julia, Didier Peter J, Reeve Aaron B, Mitsuya Hiroaki, Sarafianos Stefan G, Parniak Michael A
Abstract excerpt
Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) are essential components in first-line therapy for human immunodeficiency virus (HIV) infection. However, long-term treatment with existing NRTIs can be associated with significant toxic side effects and the emergence of drug-resistant strains. The identification of new NRTIs for the continued management of HIV-infected people therefore is paramount....
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