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Inhibition of Arenavirus by A3, a Pyrimidine Biosynthesis Inhibitor

7 Nov 2013

Abstract excerpt

Arenaviruses merit significant interest as important human pathogens, since several of them cause severe hemorrhagic fever disease that is associated with high morbidity and significant mortality. Currently, there are no FDA-licensed arenavirus vaccines available, and current antiarenaviral therapy is limited to an off-labeled use of the nucleoside analog ribavirin, which has limited prophylactic efficacy. The...

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PMID: 24198417
DOI: 10.1128/jvi.02275-13

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