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Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral Therapies.

Viruses - 14 Dec 2021

Soto-Acosta Ruben, Edwards Tiffany C, Dreis Christine D, Krishna Venkatramana D, Cheeran Maxim C-J, Qiu Li, Xie Jiashu, Bonnac Laurent F, Geraghty Robert J

Abstract excerpt

Broad-spectrum antiviral therapies hold promise as a first-line defense against emerging viruses by blunting illness severity and spread until vaccines and virus-specific antivirals are developed. The nucleobase favipiravir, often discussed as a broad-spectrum inhibitor, was not effective in recent clinical trials involving patients infected with Ebola virus or SARS-CoV-2. A drawback of favipiravir use is its...

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Identifiers

PMID: 34960780
DOI: 10.3390/v13122508
PMCID: PMC8705664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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