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Article

Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro.

Antimicrobial agents and chemotherapy - 1 Aug 2005

Nitanda Takao, Wang Xin, Kumamoto Hiroki, Haraguchi Kazuhiro, Tanaka Hiromichi, Cheng Yung-Chi, Baba Masanori

Abstract excerpt

2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine (4'-Ed4T) has been identified as a novel nucleoside analog with potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity and weak cytotoxicity in cell cultures. 4'-Ed4T proved to be 5- to 10-fold more active than its structurally related compound, stavudine (d4T). However, the drug resistance profile of 4'-Ed4T was different from those of d4T and...

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Identifiers

PMID: 16048947
DOI: 10.1128/AAC.49.8.3355-3360.2005
PMCID: PMC1196241

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Source receipt: pubmed, retrieved 7 Sept 2026.

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