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Article

Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus.

American journal of respiratory and critical care medicine - 1 Oct 2016

Bartlett Jennifer A, Ramachandran Shyam, Wohlford-Lenane Christine L, Barker Carrie K, Pezzulo Alejandro A, Zabner Joseph, Welsh Michael J, Meyerholz David K, Stoltz David A, McCray Paul B

Abstract excerpt

RATIONALE: Studies suggest that inappropriate responses to proinflammatory stimuli might contribute to inflammation in cystic fibrosis (CF) lungs. However, technical challenges have made it difficult to distinguish whether altered responses in CF airways are an intrinsic defect or a secondary effect of chronic disease in their tissue of origin. The CF pig model provides an opportunity to study the inflammatory...

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Identifiers

PMID: 27027566
DOI: 10.1164/rccm.201510-2112OC
PMCID: PMC5074652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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