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Article

Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 among Plasmodium vivax Korean isolates.

Malaria journal - 18 Jun 2012

Kang Jung-Mi, Ju Hye-Lim, Kang Yoo-Mi, Lee Dong-Hyun, Moon Sung-Ung, Sohn Woon-Mok, Park Jae-Won, Kim Tong-Soo, Na Byoung-Kuk

Abstract excerpt

BACKGROUND: The carboxy-terminal 42 kDa region of Plasmodium vivax merozoite surface protein-1 (PvMSP-1₄₂) is a leading candidate antigen for blood stage vaccine development. However, this region has been observed to be highly polymorphic among filed isolates of P. vivax. Therefore it is important to analyse the existing diversity of this antigen in the field isolates of P. vivax. In this study, the genetic...

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Identifiers

PMID: 22709605
DOI: 10.1186/1475-2875-11-206
PMCID: PMC3487983

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