Article
Genetic diversity and natural selection of Duffy binding protein of Plasmodium vivax Korean isolates.
Acta tropica - 1 Jan 2013
Ju Hye-Lim, Kang Jung-Mi, Moon Sung-Ung, Bahk Young-Yil, Cho Pyo-Yun, Sohn Woon-Mok, Park Yun-Kyu, Park Jae-Won, Kim Tong-Soo, Na Byoung-Kuk
Abstract excerpt
Plasmodium vivax Duffy binding protein (PvDBP) is a micronemal type I membrane protein that plays an essential role in erythrocyte invasion of merozoites. PvDBP is a prime blood stage vaccine candidate antigen against P. vivax, but its polymorphic nature represents a major obstacle to the successful design of a protective vaccine against vivax malaria. In this study, we analyzed the genetic polymorphism and...
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