Article
Genetic Diversity and Natural Selection in 42 kDa Region of Plasmodium vivax Merozoite Surface Protein-1 from China-Myanmar Endemic Border.
The Korean journal of parasitology - 1 Oct 2017
Zhou Xia, Tambo Ernest, Su Jing, Fang Qiang, Ruan Wei, Chen Jun-Hu, Yin Ming-Bo, Zhou Xiao-Nong
Abstract excerpt
Plasmodium vivax merozoite surface protein-1 (PvMSP1) gene codes for a major malaria vaccine candidate antigen. However, its polymorphic nature represents an obstacle to the design of a protective vaccine. In this study, we analyzed the genetic polymorphism and natural selection of the C-terminal 42 kDa fragment within PvMSP1 gene (Pv MSP142) from 77 P. vivax isolates, collected from imported cases of...
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