Article
Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data.
Human mutation - 1 Jul 2015
Wang Zhaoming, Rajaraman Preetha, Melin Beatrice S, Chung Charles C, Zhang Weijia, McKean-Cowdin Roberta, Michaud Dominique, Yeager Meredith, Ahlbom Anders, Albanes Demetrius, Andersson Ulrika, Freeman Laura E Beane, Buring Julie E, Butler Mary Ann, Carreón Tania, Feychting Maria, Gapstur Susan M, Gaziano J Michael, Giles Graham G, Hallmans Goran, Henriksson Roger, Hoffman-Bolton Judith, Inskip Peter D, Kitahara Cari M, Marchand Loic Le, Linet Martha S, Li Shengchao, Peters Ulrike, Purdue Mark P, Rothman Nathaniel, Ruder Avima M, Sesso Howard D, Severi Gianluca, Stampfer Meir, Stevens Victoria L, Visvanathan Kala, Wang Sophia S, White Emily, Zeleniuch-Jacquotte Anne, Hoover Robert, Fraumeni Joseph F, Chatterjee Nilanjan, Hartge Patricia, Chanock Stephen J
Abstract excerpt
We confirmed strong association of rs78378222:A>C (per allele odds ratio [OR] = 3.14; P = 6.48 × 10(-11) ), a germline rare single-nucleotide polymorphism (SNP) in TP53, via imputation of a genome-wide association study of glioma (1,856 cases and 4,955 controls). We subsequently performed integrative analyses on the Cancer Genome Atlas (TCGA) data for GBM (glioblastoma multiforme) and LUAD (lung adenocarcinoma)....
Read the complete abstract on PubMed