Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant.

doi:10.1038/s41467-019-13002-x

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Article

Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant.

Nature communications - 7 Nov 2019

Deng Qipan, Hu Hui, Yu Xinfang, Liu Shuanglin, Wang Lei, Chen Weiqun, Zhang Chi, Zeng Zhaoyang, Cao Ya, Xu-Monette Zijun Y, Li Ling, Zhang Mingzhi, Rosenfeld Steven, Bao Shideng, Hsi Eric, Young Ken H, Lu Zhongxin, Li Yong

Abstract excerpt

A noncoding polymorphism (rs78378222) in TP53, carried by scores of millions of people, was previously associated with moderate risk of brain tumors and other neoplasms. We find a positive association between this variant and soft tissue sarcoma. In sharp contrast, it is protective against breast cancer. We generated a mouse line carrying this variant and found that it accelerates spontaneous tumorigenesis and...

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Identifiers

PMID: 31699989
DOI: 10.1038/s41467-019-13002-x
PMCID: PMC6838078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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