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Article

Genetically attenuated Trypanosoma cruzi parasites as a potential vaccination tool.

Bioengineered - 1 Jan 2000

Pérez Brandan Cecilia, Basombrío Miguel Ángel

Abstract excerpt

Chagas disease is the clinical manifestation of the infection produced by the parasite Trypanosoma cruzi. Currently there is no vaccine to prevent this disease and the protection attained with vaccines containing non-replicating parasites is limited. Genetically attenuated trypanosomatid parasites can be obtained by deletion of selected genes. Gene deletion takes advantage of the fact that this parasite can...

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Identifiers

PMID: 22705838
DOI: 10.4161/bioe.20680
PMCID: PMC3476874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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