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Genome-Wide Meta-analysis Identifies Risk Loci and Improves Disease Prediction of Age-Related Macular Degeneration.

Ophthalmology - 1 Jan 2024

He Weixiong, Han Xikun, Ong Jue-Sheng, Wu Yeda, Hewitt Alex W, Mackey David A, Gharahkhani Puya, MacGregor Stuart

Abstract excerpt

PURPOSE: To identify age-related macular degeneration (AMD) risk loci and to establish a polygenic prediction model. DESIGN: Genome-wide association study (GWAS) and polygenic risk score (PRS) construction. PARTICIPANTS: We included 64 885 European patients with AMD and 568 740 control participants (with overlapped samples) in the UK Biobank, Genetic Epidemiology Research on Aging (GERA), International AMD...

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Identifiers

PMID: 37634759
DOI: 10.1016/j.ophtha.2023.08.023

Genes

ARMS2
CFH
CS
HIC1

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