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Article

Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Oct 2012

Wright Galen E B, Niehaus Dana J H, van der Merwe Lize, Koen Liezl, Korkie Lundi J, Kinnear Craig J, Drögemöller Britt I, Warnich Louise

Abstract excerpt

The catechol-O-methyltransferase (COMT) gene is an attractive schizophrenia candidate gene, encoding a catabolic dopamine enzyme. The enzyme exists as two distinct isoforms, with the membrane bound enzyme (i.e. MB-COMT) being predominantly expressed in the brain. Since African populations remain...

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Source

Identifiers

PMID: 22705295
DOI: 10.1016/j.pnpbp.2012.06.006

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22705295-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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