Article
Hypermethylation of p16 tumor-suppressor gene in ameloblastic carcinoma, ameloblastoma, and dental follicles.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons - 1 Jan 2013
Khojasteh Arash, Khodayari Abbas, Rahimi Farzaneh, Ghaderian Mohamad Hossain, Jafarian Mohamad, Nayebi Alireza, Akbarzadeh Najar Reza, Tabatabayipanah Akram, Jahangirnia Alireza
Abstract excerpt
PURPOSE: The high rate of p16 gene alterations in malignant neoplasms suggests the important effect of this tumor-suppressor gene mutation on the malignant behavior of tumoral lesions. The present study investigated the possible methylation of the p16 tumor in ameloblastic carcinoma, ameloblastoma, and dental follicles. MATERIALS AND METHODS: Eighteen samples of ameloblastic carcinoma, ameloblastoma, and dental...
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