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Article

Methylation of P16, P21, P27, RB1 and P53 genes in odontogenic keratocysts

23 Dec 2008

Abstract excerpt

BACKGROUND: Odontogenic keratocyst (OKC) is a benign neoplasm with an aggressive clinical behavior and a high recurrence rate. Although epigenetic alterations have been reported in different tumors, these events were not investigated in OKC yet. The aim of this study was to investigate the presence of methylation in P16, P21, P27, P53 and RB1 genes in OKC tumors. METHODS: Methylation-specific polymerase chain...

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PMID: 19192054
DOI: 10.1111/j.1600-0714.2008.00718.x

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