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Article

Time course of glucose metabolism in relation to cognitive performance and postmortem neuropathology in Met146Val PSEN1 mutation carriers.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Schöll Michael, Almkvist Ove, Bogdanovic Nenad, Wall Anders, Långström Bengt, Viitanen Matti, Nordberg Agneta

Abstract excerpt

Studies in carriers of mutations that cause early-onset familial Alzheimer’s disease (eoFAD) are of significant interest.We showed previously that regional glucose hypometabolism could be detected many years before disease onset in presenilin 1(PSEN1) mutation carriers. Here we studied four members of a family with a Met146Val PSEN1 mutation, two symptomatic carriers and two non-carriers, longitudinally with...

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Source

Identifiers

PMID: 21297272
DOI: 10.3233/JAD-2011-101563

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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