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Article

Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease.

Neuro-degenerative diseases - 1 Jan 2009

Portelius Erik, Zhang Bin, Gustavsson Mikael K, Brinkmalm Gunnar, Westman-Brinkmalm Ann, Zetterberg Henrik, Lee Virginia M-Y, Trojanowski John Q, Blennow Kaj

Abstract excerpt

BACKGROUND: Accumulation of amyloid beta (Abeta) in the brain is believed to represent one of the earliest events in the Alzheimer disease process. Abeta is generated from amyloid precursor protein after sequential cleavage by beta- and gamma-secretase. Alternatively, alpha-secretase cleaves with...

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Identifiers

PMID: 19955704
DOI: 10.1159/000264639
PMCID: PMC2837891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19955704-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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