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Article

Does a loss of TDP-43 function cause neurodegeneration?

Molecular neurodegeneration - 14 Jun 2012

Xu Zuo-Shang

Abstract excerpt

In 2006, TAR-DNA binding protein 43 kDa (TDP-43) was discovered to be in the intracellular aggregates in the degenerating cells in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two fatal neurodegenerative diseases [1,2]. ALS causes motor neuron degeneration leading to paralysis [3,4]. FTLD causes neuronal degeneration in the frontal and temporal cortices leading to personality...

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Identifiers

PMID: 22697423
DOI: 10.1186/1750-1326-7-27
PMCID: PMC3419078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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