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Article

TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?

Trends in molecular medicine - 1 Feb 2014

Vanden Broeck Lies, Callaerts Patrick, Dermaut Bart

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are clinically distinct fatal neurodegenerative disorders. Increasing molecular evidence indicates that both disorders are linked in a continuous spectrum (ALS-FTD spectrum). Neuronal cytoplasmic inclusions consisting of the nuclear TAR DNA-binding protein 43 (TDP-43) are found in the large majority of patients in the ALS-FTD spectrum and...

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Identifiers

PMID: 24355761
DOI: 10.1016/j.molmed.2013.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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