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[Neuropathology of TDP-43 proteinopathy].

Brain and nerve = Shinkei kenkyu no shinpo - 1 Dec 2013

Akiyama Haruhiko, Hasegawa Masato

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) is a member of the heterogeneous nuclear ribonucleoprotein family, a group of proteins involved in pre-mRNA splicing, RNA stability, transport, and metabolism. TDP-43 was identified as the major component of pathological protein aggregates present in a subset of frontotemporal lobar degeneration (FTLD), which is now referred to as FTLD-TDP. TDP-43 is also deposited in the...

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PMID: 24323933

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