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Article

The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player?

7 Sept 2020

Abstract excerpt

Metastasis is known as the most life-threatening event in cancer patients. In principle, the immune system can prevent tumor development. However, dysfunctional T cells may fail to eliminate the tumor cells effectively and provide additional survival advantages for tumor proliferation and metastasis. Constitutive activation of Ras-associated protein1 (Rap1) has not only led to T cell anergy, but also inhibited...

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PMID: 32906721
DOI: 10.3390/biomedicines8090334

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