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Article

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.

The Journal of allergy and clinical immunology - 1 Oct 2012

Li Xingnan, Ampleford Elizabeth J, Howard Timothy D, Moore Wendy C, Torgerson Dara G, Li Huashi, Busse William W, Castro Mario, Erzurum Serpil C, Israel Elliot, Nicolae Dan L, Ober Carole, Wenzel Sally E, Hawkins Gregory A, Bleecker Eugene R, Meyers Deborah A

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASs) of asthma have consistently implicated the ORM1-like 3 and gasdermin B (ORMDL3-GSDMB), IL33, IL-1 receptor-like 1 and IL-18 receptor 1 (IL1RL1-IL18R1), RAD50-IL13, thymic stromal lymphopoietin and WD repeat domain 36 region (TSLP-WDR36), and HLA-DR/DQ regions. OBJECTIVE: A GWAS of asthma was performed in a non-Hispanic white population. METHODS: A GWAS was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22694930
DOI: 10.1016/j.jaci.2012.04.041
PMCID: PMC3579216

Genes

GSDMB
TNFAIP3
TNIP1
ORM1
ORMDL3
RAD50
TNF
TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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