Article

Research on the Anti-tumor Activity of Novel Histone Deacetylase Inhibitors based on 3D QSAR Model

2023-10-11

Abstract excerpt

<h4>Background: </h4> Histone deacetylases (HDACs) pertain to the category of Zn 2+ or nicotinamide adenine dinucleotide (NAD+)-dependent proteolytic enzymes. While the antitumor effect of HDAC inhibitors alone has been demonstrated and the effect of HDAC inhibitors on solid tumors is not ideal, which considerably limits their clinical use. Therefore, the search for novel HDAC inhibitors equipped with specific inh...

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Literature Corpus work: 99396279-5323-5149-a4ba-9f28cba37b4c
DOI: 10.21203/rs.3.rs-3410389/v1

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