Article
Highly activatable and environment-insensitive optical highlighters for selective spatiotemporal imaging of target proteins.
Journal of the American Chemical Society - 11 Jul 2012
Kobayashi Tomonori, Komatsu Toru, Kamiya Mako, Campos Cláudia, González-Gaitán Marcos, Terai Takuya, Hanaoka Kenjiro, Nagano Tetsuo, Urano Yasuteru
Abstract excerpt
Optical highlighters are photoactivatable fluorescent molecules that exhibit pronounced changes in their spectral properties in response to irradiation with light of a specific wavelength and intensity. Here, we present a novel design strategy for a new class of caged BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) fluorophores, based on the use of photoremovable protecting groups (PRPGs) with high reduction...
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