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Article

Plasticity and epistasis strongly affect bacterial fitness after losing multiple metabolic genes.

Evolution; international journal of organic evolution - 1 May 2015

D'Souza Glen, Waschina Silvio, Kaleta Christoph, Kost Christian

Abstract excerpt

Many bacterial lineages lack seemingly essential metabolic genes. Previous work suggested selective benefits could drive the loss of biosynthetic functions from bacterial genomes when the corresponding metabolites are sufficiently available in the environment. However, the factors that govern this "genome streamlining" remain poorly understood. Here we determine the effect of plasticity and epistasis on the...

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Identifiers

PMID: 25765095
DOI: 10.1111/evo.12640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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