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Article

Genome-wide association study of lung function decline using elastic-net regression: a prospective analysis in Korean cohort.

Human genomics - 1 Dec 2025

Bae Eunhye, Oh Sohee, Lee Jung-Kyu, Heo Eun Young, Kim Deog Kyeom, Lee Hyun Woo

Abstract excerpt

BACKGROUND: A rapid decline in forced expiratory volume in one second (FEV1) can lead to chronic airway disease and is associated with poor prognosis. This study aims to identify single nucleotide polymorphisms (SNPs) associated with the annual rate of FEV1 decline, investigate the differential effects based on various phenotypes, and develop a genetic risk score (GRS) for predicting rapid FEV1 decline. METHODS:...

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Identifiers

PMID: 41327349
DOI: 10.1186/s40246-025-00862-2
PMCID: PMC12771834

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