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Sclerostin and DKK1 in postmenopausal osteoporosis treated with denosumab

12 Jun 2012

Abstract excerpt

The bone mass benefits of antiresorbers in postmenopausal osteoporosis are limited by the rapid coupling of decreasing bone resorption with bone formation. Wnt signaling is involved in this coupling process during treatment with bisphosphonates, whereas its role during treatment with the anti-receptor activator of NF-κB ligand (RANKL) antibody denosumab is unknown. The study population includes patients...

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PMID: 22692843
DOI: 10.1002/jbmr.1681

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