Article
The Regulation of Bone Metabolism and Disorders by Wnt Signaling.
International journal of molecular sciences - 6 Nov 2019
Maeda Kazuhiro, Kobayashi Yasuhiro, Koide Masanori, Uehara Shunsuke, Okamoto Masanori, Ishihara Akihiro, Kayama Tomohiro, Saito Mitsuru, Marumo Keishi
Abstract excerpt
Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a cytokine involved in various biological phenomena including ontogeny, morphogenesis, carcinogenesis, and maintenance of stem cells. The Wnt signaling pathway can be classified into two main pathways: canonical and non-canonical. Of these, the canonical Wnt signaling pathway promotes osteogenesis. Sclerostin produced by...
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