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Article

Germline mutations in BRIP1 and PALB2 in Jewish high cancer risk families.

Familial cancer - 1 Sept 2012

Catucci Irene, Milgrom Roni, Kushnir Anya, Laitman Yael, Paluch-Shimon Shani, Volorio Sara, Ficarazzi Filomena, Bernard Loris, Radice Paolo, Friedman Eitan, Peterlongo Paolo

Abstract excerpt

Germline mutations in BRCA1 and BRCA2 account for ~30 % of inherited breast cancer. BRIP1 and PALB2 are likely genes for breast cancer susceptibility, based on their roles in maintaining cellular integrity. Indeed, few pathogenic germline mutations in both genes are reported in ethnically diverse breast cancer families. There is a paucity of data on the putative contribution of both genes to inherited breast...

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Source

Identifiers

PMID: 22692731
DOI: 10.1007/s10689-012-9540-8

Genes

BRIP1
PALB2
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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