Article
Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years.
Cancer research - 15 Aug 2006
Malone Kathleen E, Daling Janet R, Doody David R, Hsu Li, Bernstein Leslie, Coates Ralph J, Marchbanks Polly A, Simon Michael S, McDonald Jill A, Norman Sandra A, Strom Brian L, Burkman Ronald T, Ursin Giske, Deapen Dennis, Weiss Linda K, Folger Suzanne, Madeoy Jennifer J, Friedrichsen Danielle M, Suter Nicola M, Humphrey Mariela C, Spirtas Robert, Ostrander Elaine A
Abstract excerpt
Although well studied in families at high-risk, the roles of mutations in the BRCA1 and BRCA2 genes are poorly understood in breast cancers in the general population, particularly in Black women and in age groups outside of the very young. We examined the prevalence and predictors of BRCA1 and BRCA2 mutations in 1,628 women with breast cancer and 674 women without breast cancer who participated in a multicenter...
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