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Article

Detection of allele-specific methylation through a generalized heterogeneous epigenome model.

Bioinformatics (Oxford, England) - 15 Jun 2012

Peng Qian, Ecker Joseph R

Abstract excerpt

MOTIVATIONS: High-throughput sequencing has made it possible to sequence DNA methylation of a whole genome at the single-base resolution. A sample, however, may contain a number of distinct methylation patterns. For instance, cells of different types and in different developmental stages may have different methylation patterns. Alleles may be differentially methylated, which may partially explain that the large...

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Identifiers

PMID: 22689757
DOI: 10.1093/bioinformatics/bts231
PMCID: PMC3371863

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