Article
Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions.
The pharmacogenomics journal - 1 Aug 2013
Grajales-Reyes G E, Báez-Pagán C A, Zhu H, Grajales-Reyes J G, Delgado-Vélez M, García-Beltrán W F, Luciano C A, Quesada O, Ramírez R, Gómez C M, Lasalde-Dominicci J A
Abstract excerpt
High cholesterol levels are an established risk factor for cardiovascular disease (CVD), the world's leading cause of death. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (statins) are prescribed to lower serum cholesterol levels and reduce the risk of CVD. Despite the success of statins, many patients abandon treatment owing to neuromuscular adverse drug reactions (ADRs). Genome-wide association...
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