Effect of SLCO1B1 T521C on Statin-Related Myotoxicity With Use of Lovastatin and Atorvastatin.

doi:10.1002/cpt.2337

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Article

Effect of SLCO1B1 T521C on Statin-Related Myotoxicity With Use of Lovastatin and Atorvastatin.

Clinical pharmacology and therapeutics - 1 Sept 2021

Lu Brian, Sun Laura, Seraydarian Manuel, Hoffmann Thomas J, Medina Marisa W, Risch Neil, Iribarren Carlos, Krauss Ronald M, Oni-Orisan Akinyemi

Abstract excerpt

The association between the c.521T>C variant allele in SLCO1B1 (reference single nucleotide polymorphism (rs)4149056) and simvastatin-induced myotoxicity was discovered over a decade ago; however, whether this relationship represents a class effect is still not fully known. The aim of this study was to investigate the relationship between rs4149056 genotype and statin-induced myotoxicity in patients taking...

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Identifiers

PMID: 34114646
DOI: 10.1002/cpt.2337
PMCID: PMC8376784

Genes

SLCO1B1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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