Article
Characterisation of the structure of ocr, the gene 0.3 protein of bacteriophage T7.
Nucleic acids research - 15 Jul 2001
Atanasiu C, Byron O, McMiken H, Sturrock S S, Dryden D T
Abstract excerpt
The product of gene 0.3 of bacteriophage T7, ocr, is a potent inhibitor of type I DNA restriction and modification enzymes. We have used biophysical methods to examine the mass, stability, shape and surface charge distribution of ocr. Ocr is a dimeric protein with hydrodynamic behaviour equivalent to a prolate ellipsoid of axial ratio 4.3 +/- 0.7:1 and mass of 27 kDa. The protein is resistant to denaturation but...
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