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Article

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

Nature neuroscience - 10 Jun 2012

de Anda Froylan Calderon, Rosario Ana Lucia, Durak Omer, Tran Tracy, Gräff Johannes, Meletis Konstantinos, Rei Damien, Soda Takahiro, Madabhushi Ram, Ginty David D, Kolodkin Alex L, Tsai Li-Huei

Abstract excerpt

How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of basal dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 kinase (TAOK2), also known as TAO2, is essential for dendrite morphogenesis. TAOK2 downregulation impairs basal dendrite formation in vivo without...

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Identifiers

PMID: 22683681
DOI: 10.1038/nn.3141
PMCID: PMC4017029

Genes

TAOK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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